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In a meta-analysis of the study of the role of homocysteine ​​in the development of atherosclerosis, it was found that the correlation coefficient between coronary artery disease and stroke was 1.5 for every 5 µmol/l increase in homocysteine. There is a similar relationship with ZANK.
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Hyperhomocysteinemia is believed to increase the risk of revia to LAD, however, the etiological role of homocysteine ​​remains unknown, as no studies have been reported investigating the decrease in homocysteine ​​levels in LAD. Elevated levels of C-reactive protein (CRP). CRP, a serum marker of systemic inflammation, is associated with LAD. The Physicians' Health Study found that CRP levels were higher in individuals who subsequently developed LAD and much higher in patients operated on for LAD.